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Biological Effects of Long‐Duration, High‐Field (4 T) MRI on Growth and Development in the Mouse
Author(s) -
Magin Richard L.,
Lee John K.,
Klintsova Anna,
Carnes Kay I.,
Dunn Floyd
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200007)12:1<140::aid-jmri15>3.0.co;2-d
Subject(s) - ultrasound , magnetic resonance imaging , fetus , medicine , fetal weight , nuclear medicine , radiology , pregnancy , biology , genetics
The effects of long‐duration, high‐field magnetic resonance imaging (MRI) on fetal growth and postnatal development in mice were studied. Seven experimental groups of pregnant ICR mice were exposed for 9 hours on day 9 and/or day 12 post coitus (pc) to magnetic fields (4 T static, 5 T/sec switched gradient, and 0.2 W/kg radiofrequency at 170 MHz) associated with MRI conditions. Two experimental groups (sham and exposure groups) were exposed to a combination of ultrasound (day 9 pc, 3.25 MHz, focused) and MRI‐associated fields (day 12 pc). No statistically significant changes in fetal growth were observed in the animals exposed to only MRI or ultrasound fields. However, in the combined ultrasound and MRI‐exposed group, the fetal weight and crown‐rump length were reduced compared with the sham and cage controls. These results suggest that MRI and ultrasound exposure well in excess of current clinical conditions can exert biological effects if applied at sensitive stages of fetal development. J. Magn. Reson. Imaging 2000;12:140–149. © 2000 Wiley‐Liss, Inc.