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Subchronic In Vivo Effects of a High Static Magnetic Field (9.4 T) in Rats
Author(s) -
High Wanda B.,
Sikora Joseph,
Ugurbil Kamil,
Garwood Michael
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200007)12:1<122::aid-jmri14>3.0.co;2-c
Subject(s) - offspring , physiology , litter , urinary system , in vivo , gestation , medicine , endocrinology , biology , pregnancy , genetics , microbiology and biotechnology , agronomy
The potential adverse biologic effects of sub chronic (cumulatively 10 weeks) exposure to a high magnetic field (9.4 T) were evaluated in young adult male and female Fischer rats as well as in their progeny. Biologic end points in adult rats included changes in daily clinical observations; spatial memory tests; weekly heart rates, body weights, food and water consumption, and the feed efficiency ratio; terminal hematologic, blood biochemical and urinary parameter changes; gross pathologic findings; and major organ weights. In offspring, biologic end points included the gestation period, number of live births, number of pups, ratio of male to female pups/litter; postnatal time period of eye opening; birth and weekly body weights, behavorial changes, central nervous system responses, as well as hematologic, blood biochemistry, and urinary parameter changes; and gross pathologic findings. Findings from this study showed that there were no adverse biologic effects in male and female adult rats or their progeny that could be attributed to 10‐week exposure to a 9.4‐T static magnetic field. J. Magn. Reson. Imaging 2000;12:122–139. © 2000 Wiley‐Liss, Inc.