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Correlation of high‐resolution breast MR imaging with histopathology; validation of a technique
Author(s) -
Holland Agnes E.,
Hendrick R. Edward,
Jin Haoran,
Russ Paul D.,
Barentsz Jelle O.,
Holland Roland
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200006)11:6<601::aid-jmri5>3.0.co;2-g
Subject(s) - histopathology , magnetic resonance imaging , flip angle , high resolution , nuclear medicine , breast mri , histology , medicine , nuclear magnetic resonance , mammography , materials science , radiology , pathology , breast cancer , physics , cancer , remote sensing , geology
A high‐resolution three‐dimensional surface gradient coil set was used to obtain magnetic resonance (MR) images of breast specimens, using a gradient‐echo pulse sequence (TR/TE 1000/8 msec, flip angle 75°), with 117 μm in‐plane resolution and 1 mm slice thickness. Breast tissues were obtained from one autopsy and three surgical specimens. High‐resolution breast MR images and histopathology sections (7 μm thickness) were acquired in the same anatomical plane. Radiographs were acquired of the sliced specimens (approximately 5 mm thick) so that images from all three methods could be correlated. It was found that in vitro high‐resolution breast MRI correlated well with low‐resolution microscopic histology, demonstrating normal anatomy (lobules, ducts, connective tissue strands, blood vessels) and pathology (tumor content, margins, and presence of microcalcifications) of the breast more clearly than conventional pre‐gadolinium breast MRI. High‐resolution breast MRI may improve specificity, when added to a conventional breast MRI protocol. J. Magn. Reson. Imaging 2000;11:601–606. © 2000 Wiley‐Liss, Inc.