Premium
New 2 H ‐Tetrahydro‐1, 3, 5‐thiadiazine‐2‐thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents
Author(s) -
AboulFadl Tarek,
Hussein Mostafa A.,
ElShorbagi AbdelNasser,
Khallil AbdelRaouf
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200212)335:9<438::aid-ardp438>3.0.co;2-e
Subject(s) - penicillium expansum , trichophyton rubrum , aspergillus flavus , chemistry , candida albicans , aflatoxin , glycine , fungi imperfecti , microbiology and biotechnology , fusarium oxysporum , antifungal , botrytis cinerea , biological activity , antimicrobial , in vitro , organic chemistry , biochemistry , amino acid , biology , botany , food science , postharvest
The new title derivatives ( 4b—h and 5a—i ) were synthesized by reaction of the appropriate primary amine, carbon disulphide, and formaldehyde. These derivatives were prepared in order to study the effects of introducing polar groups at N3 or N5 or at both positions on the biological activity. The compounds were tested for their antifungal activity in vitro against pathogenic ( Trichophyton rubrum and Candida albicans ), phytopathogenic ( Penicillum expansum, Trichoderma hazianum, and Fasarium oxysporum ), and aflatoxin‐producing ( Aspergillus flavus ) fungi. These compounds exhibited varied inhibitory effects on growth or sporulation of some tested fungal species.