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Stereoselective Synthesis and in Vitro Antifungal Evaluation of ( E )‐ and ( Z )‐Imidazolylchromanone Oxime Ethers
Author(s) -
Emami Saeed,
Falahati Mehraban,
Banifatemi Ali,
Moshiri Kayvan,
Shafiee Abbas
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200209)335:7<318::aid-ardp318>3.0.co;2-o
Subject(s) - microsporum gypseum , candida albicans , chemistry , oxime , stereoselectivity , stereochemistry , in vitro , aspergillus niger , antifungal , chemical synthesis , biological activity , organic chemistry , microbiology and biotechnology , biochemistry , biology , trichophyton , catalysis
A series of ( E )‐ and ( Z )‐2, 3‐dihydro‐3‐(1 H ‐imidazol‐1‐yl)‐4 H ‐1‐benzopyran‐4‐one oxime ethers have been synthesized and tested for antifungal activity. Most compounds showed moderate to potent in vitro antifungal activity. Among the tested compounds, compound ( E )‐ 3d was the most active agent against Candida albicans and Aspergillus niger , and compounds ( Z )‐( 3a ) and ( E )‐ 3a were the most potent compounds against Microsporum gypseum . Detailed stereoselective synthesis, spectroscopic, and biological data are reported.