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Synthesis and Antimicrobial Activity of Some 2‐[ p ‐Substituted‐phenyl]benzoxazol‐5‐yl‐arylcarboxyamides
Author(s) -
TemizArpaci Özlem,
AkiŞener Esin,
Yalçin Ismail,
Altanlar Nurten
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200208)335:6<283::aid-ardp283>3.0.co;2-m
Subject(s) - antimicrobial , chemistry , bacteria , candida albicans , proton nmr , corpus albicans , dilution , gram , minimum inhibitory concentration , stereochemistry , nuclear chemistry , yeast , organic chemistry , biochemistry , microbiology and biotechnology , biology , genetics , physics , thermodynamics
New 2‐[ p ‐substituted‐phenyl ]benzoxazol‐5‐yl‐arylcarboxyamides derivatives have been synthesized by reacting 5‐amino‐2‐[ p ‐substituted‐phenyl ]benzoxazoles with substituted‐arylcarboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR and 1 H NMR spectral data. Antimicrobial activities of the compounds were investigated using the two‐fold serial dilution technique against different Gram‐positive and Gram‐negative bacteria and the yeast C . albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possess a broad spectrum of activity, having an MIC value of 25‐200 μg/mL at molar concentration values of 3.45 ? 10 ‐5 and 5.74 ? 10 ‐4 against the tested microorganisms.