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Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted thiazolidinopyrrolidin‐3‐ylthio)carbapenems and Related Compounds
Author(s) -
Oh ChangHyun,
Cho HanWon,
Lee InKyu,
Gong JaiYang,
Choi JoungHoon,
Cho JungHyuck
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200204)335:4<152::aid-ardp152>3.0.co;2-b
Subject(s) - thiazolidine , moiety , antibacterial activity , chemistry , substituent , amide , antibacterial agent , stereochemistry , lactam , chemical synthesis , ring (chemistry) , structure–activity relationship , bacteria , in vitro , organic chemistry , antibiotics , biochemistry , biology , genetics
The synthesis of a new series of 1β‐methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated.A particular compound ( 18 c ) having a 2‐amide substituted thiazolidine moiety showed the most potent antibacterial activity.