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Preparation and Antibacterial Activity of 3‐Methyl‐1‐ p ‐substituted Phenylpyrazole‐5‐thiol
Author(s) -
Tagawa Yoshinobu,
Minami Shin'ichi,
Yoshida Toshio,
Tanaka Keitaro,
Sato Shuji,
Goto Yoshinobu,
Yamagata Kenji
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200203)335:2/3<99::aid-ardp99>3.0.co;2-2
Subject(s) - antimicrobial , thiol , chemistry , antibacterial activity , antibacterial agent , combinatorial chemistry , staphylococcus epidermidis , stereochemistry , staphylococcus aureus , bacteria , organic chemistry , antibiotics , biochemistry , biology , genetics
3‐Methyl‐1‐phenylpyrazole‐5‐thiol ( 3a ) and its p ‐nitro‐( 5 ) and p ‐fluorophenyl ( 8 ) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pyogenes . Moreover, compound 3a also showed a synergistic effect with some aminoglycosides.