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Synthesis and Antimicrobial Activity of Hydroxyalkyl‐ and Hydroxyacyl‐phenols and Their Benzyl Ethers
Author(s) -
Krauß Jürgen,
Unterreitmeier D.
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200203)335:2/3<94::aid-ardp94>3.0.co;2-w
Subject(s) - chemistry , antimicrobial , phenols , bacteria , aspergillus niger , dihydroxylation , organic chemistry , candida glabrata , candida albicans , stereochemistry , microbiology and biotechnology , biochemistry , biology , catalysis , enantioselective synthesis , genetics
New phenolic compounds with hydrophilic side chains were prepared from 4‐benzyloxybenzaldehyde and alkenyl magnesium bromides, followed by Sharpless dihydroxylation and hydrogenolytic removal of the benzyl group. The resulting compounds were tested in an agar diffusion assay against gram positive bacteria, gram negative bacteria, and against the fungi Candida glabrata and Aspergillus niger .