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Synthesis of Imidazo[2, 1‐ a ]phthalazines, Potential Inhibitors of p38 MAP Kinase. Prediction of Binding Affinities of Protein Ligands
Author(s) -
Mavel Sylvie,
Thery Isabelle,
Gueiffier Alain
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200201)335:1<7::aid-ardp7>3.0.co;2-l
Subject(s) - pharmacophore , affinities , chemistry , binding affinities , p38 mitogen activated protein kinases , kinase , stereochemistry , combinatorial chemistry , mitogen activated protein kinase , protein kinase a , biochemistry , receptor
Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen‐activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2, 1‐ a ]phthalazines obtained by Suzuki coupling are described.