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Investigation of Antiulcer Activities of Imidazo[1,2‐6alpha;]pyridinyl‐2‐alkylaminobenzoxazoles and 5,6,7,8‐Tetahydroimidazo[1,2‐alpha;]pyridinylbenzoxazoles with Electron‐Topological (ET) Method
Author(s) -
Guzel Yahya,
Kopar A. K.
Publication year - 2002
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200201)335:1<27::aid-ardp27>3.0.co;2-v
Subject(s) - alpha (finance) , topology (electrical circuits) , molecule , chemistry , series (stratigraphy) , stereochemistry , biological activity , fragment (logic) , mathematics , in vitro , biochemistry , combinatorics , organic chemistry , biology , algorithm , construct validity , statistics , psychometrics , paleontology
The study presents structure‐activity considerations of a series of imidazo[1,2‐α]pyridiny‐2‐alkylaminobenzoxazoles (I) and 5,6,7,8‐tetahydroimidazo[1,2‐α]pyridinylbenzoxazoles (II) investigated for anti‐stress ulcer activity with the electron‐topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron‐topological method in an active molecule is responsible for anti‐stress ulcer activity. Quantitative structure‐activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF‐7.0.