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Synthesis of vinca alkaloids and related compounds, Part XCVI [1] Nitration study of vinblastine‐type bisindole alkaloids
Author(s) -
Szabó Lajos,
Bölcskei Hedvig,
Eszter BaitzGács,
Mák Marianna,
Szántay Csaba
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:12<399::aid-ardp399>3.0.co;2-1
Subject(s) - vinca , vinblastine , chemistry , nitration , stereochemistry , alkaloid , pharmacology , organic chemistry , medicine , chemotherapy
Abstract The bisindole alkaloids vinblastine, vincristine, and N ‐formyl‐leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non‐small cell lung cancer and breast cancer in the concentration range tested (10 −5 — 10 −9 M). 5b also showed potency in the screen for colon cancer and leukemia.