Premium
Synthesis and analgesic‐antiinflammatory activities of novel acylarylhydrazones with a 5‐phenyl‐4‐R‐3‐pyrrolyl‐acyl moiety
Author(s) -
Murineddu Gabriele,
Loriga Giovanni,
Gavini Elisabetta,
Peana Alessandra T.,
Mulè Antonio C.,
Pinna Gérard A.
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:12<393::aid-ardp393>3.0.co;2-p
Subject(s) - analgesic , carbohydrazide , chemistry , indometacin , moiety , pyrrole , pharmacology , stereochemistry , medicine , medicinal chemistry , cyclooxygenase , biochemistry , organic chemistry , prostaglandin endoperoxide synthase , enzyme
A new series of arylidene 5‐phenyl‐4‐R‐pyrrole‐3‐carbohydrazides 1a—j were prepared and evaluated for their analgesic‐antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 μM/kg. Two of these, 1b , (4'‐methylbenzylidene)‐5‐phenyl‐1 H ‐pyrrole‐3‐carbohydrazide, and 1d , (4'‐chlorobenzylidene)‐5‐phenyl‐1 H ‐pyrrole‐3‐carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1 , only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflammatory analgesic.