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Effect of oxovanadium(IV) complexes on nondiabetic and streptozotocin‐diabetic rats
Author(s) -
Krosniak Miroslaw,
Zachwieja Zofia,
Filipek Barbara,
Zygmunt Malgorzata,
Grybos Ryszard
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:12<388::aid-ardp388>3.0.co;2-9
Subject(s) - streptozotocin , vanadium , chemistry , diabetes mellitus , medicine , plasma glucose , total cholesterol , toxicity , endocrinology , cholesterol , stereochemistry , biochemistry , inorganic chemistry
The effects of vanadium complexes with organic ligands, [VO(phen) 2 ]SO 42 · 3H 2 O, [VO(bpy) 2 ]SO 4 · 2H 2 O, and [VOCl 2 (Hmcp) 2 H 2 O], on blood glucose and plasma lipid levels were studied in nondiabetic and streptozotocin‐diabetic rats and compared to that of [VO(mal) 2 ] (the reference compound). The present results provide evidence that the compounds examined possess lower toxicity than [VO(mal) 2 ]. One of the compounds examined, viz. [VO(bpy) 2 ]SO 4 · 2H 2 O, decreases, statistically significantly, the glucose level and a second one, viz. [VOCl 2 (Hmcp) 2 H 2 O], decreases, also significantly, the total cholesterol level.