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Synthesis, antimicrobial, and alkylating properties of 3‐phosphonic derivatives of chromone
Author(s) -
Budzisz Elzbieta,
Nawrot Ewa,
Malecka Magdalena
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:12<381::aid-ardp381>3.0.co;2-0
Subject(s) - chromone , phosphonate , chemistry , antimicrobial , yield (engineering) , pyridine , antibacterial activity , bacteria , stereochemistry , derivative (finance) , gram , organic chemistry , combinatorial chemistry , biology , materials science , economics , financial economics , metallurgy , genetics
Dimethyl 2,6‐dimethyl‐4‐oxo‐4 H ‐chromen‐3‐yl‐phosphonate ( 1a ) and dimethyl 6‐methyl‐2‐phenyl‐4‐oxo‐4 H ‐chromen‐3‐yl‐phosphonate ( 1b ) were synthesized and reacted with primary aliphatic amines to yield title compounds 4—6 . Their antibacterial properties against Gram‐positive and Gram‐negative bacteria strains were tested by the MIC method. Four of seventeen tested compounds ( 1d, 3, 4a, and 4b ) exhibit detectable activity against S. aureus . Some representative examples of newly synthesized compounds were tested for their alkylating properties in vitro in the Preussmann test. Compounds 1a, 1c, 1d, 3, 5d, and 6a possess highly alkylating activity toward standard derivative 4‐(4'‐nitrobenzyl)pyridine (NBP).