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Anticonvulsant activity of reaction products of 5,5‐diphenylhydantoin with substituted methylene bromides
Author(s) -
Usifoh Cyril O.
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:11<366::aid-ardp366>3.0.co;2-q
Subject(s) - phenytoin , anticonvulsant , chemistry , methylene , neurotoxicity , alkylation , pharmacology , epilepsy , medicinal chemistry , toxicity , organic chemistry , medicine , catalysis , psychiatry
Abstract Some derivatives of 5,5‐diphenylhydantoin (phenytoin) were synthesized by the alkylation of phenytoin with substituted methylene bromides. The hydantoins were evaluated for possible anticonvulsant activity in the maximal electroshock (MES)‐ and subcutaneous pentylenetetrazole (ScMet)‐induced seizures and for neurotoxicity in the rotorod test in mice and rats.