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Synthesis and antimicrobial activities of 5‐fluoro‐1,2,6‐trisubstituted benzimidazole carboxamide and acetamide derivatives
Author(s) -
Kus Canan,
Göker Hakan,
Altanlar Nurten
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200112)334:11<361::aid-ardp361>3.0.co;2-9
Subject(s) - benzimidazole , acetamide , chemistry , antimicrobial , candida albicans , carboxamide , antifungal , candida tropicalis , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , microbiology and biotechnology , biology , yeast
Some 5‐fluoro‐6‐substitute‐1 H ‐benzimidazole‐2‐carbamates ( 12a—e ), 5‐fluoro‐6‐substituted 1 H ‐benzimidazole‐2‐acetate ( 13a—e ) and 2‐acetamide ( 14a—f ) derivatives, 2‐acetamido‐5‐fluoro‐6‐(morpholin‐4‐yl)‐1‐propyl‐1 H ‐benzimidazole ( 15 ), and 1‐cyclopropyl‐2‐ethyl‐5‐fluoro‐6‐(4‐methylpiperazin‐1‐yl)‐1 H ‐benzimidazole ( 16 ) were synthesized, and their antimicrobial and antifungal activities evaluated. Compound 12c exhibited the best activity against Candida albicans .