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Potential Tuberculostatic Agents: Micelle‐Forming Copolymer Poly(ethylene glycol)‐Poly(aspartic acid) Prodrug with Isoniazid
Author(s) -
Silva M.,
Lara A. S.,
Leite C. Q. F.,
Ferreira E. I.
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200106)334:6<189::aid-ardp189>3.0.co;2-6
Subject(s) - prodrug , isoniazid , ethylene glycol , micelle , copolymer , aspartic acid , chemistry , mycobacterium tuberculosis , organic chemistry , tuberculosis , aqueous solution , biochemistry , amino acid , medicine , polymer , pathology
With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.