Premium
Synthesis of Imidazo[4,5‐ d ]oxazolo[3,4‐ a ]pyridines. New Heterocyclic Analogues of Lignans
Author(s) -
Madrigal Blanca,
Puebla Pilar,
Caballero Esther,
Peláez Rafael,
Grávalos Dolores Ga,
Medarde Manuel
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200105)334:5<177::aid-ardp177>3.0.co;2-k
Subject(s) - chemistry , stereochemistry , imidazole , ring (chemistry) , cytotoxicity , lignan , bicyclic molecule , combinatorial chemistry , organic chemistry , in vitro , biochemistry
The preparation of new analogues of lignans carrying an imidazole ring has been achieved. Starting from L ‐histidinol, cis and trans stereoisomers have been obtained. The synthesized products lack the cytotoxicity displayed by related podophyllotoxins and azatoxin.