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Aryl Rings Are Part of the Darpone Pharmacophore
Author(s) -
Schultz Christiane,
Link Andreas,
Kunick Conrad
Publication year - 2001
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200105)334:5<163::aid-ardp163>3.0.co;2-3
Subject(s) - pharmacophore , aryl , chemistry , stereochemistry , structure–activity relationship , cancer cell lines , combinatorial chemistry , cancer cell , in vitro , cancer , biochemistry , organic chemistry , alkyl , biology , genetics
In order to investigate structure‐activity relationships in the antiproliferative darpone series, the derivatives 8a and 8b lacking the aryl substituents in either 2‐ or 4‐position were synthesized and evaluated for cancer cell growth inhibition. Since both 8a and 8b were devoid of noteworthy antiproliferative activity, both aryl substituents can be considered as part of the darpone pharmacophore.