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Synthesis of 5‐Substituted Pyrrolo[1,2‐ b ]pyridazines with Antioxidant Properties
Author(s) -
Østby Ole Benny,
Gundersen LiseLotte,
Rise Frode,
Antonsen Øyvind,
Fosnes Kjetil,
Larsen Vibeke,
Bast Aalt,
Custers Ilse,
Haenen Guido R. M. M.
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w
Subject(s) - pyridazine , lipid peroxidation , chemistry , ascorbic acid , antioxidant , thiobarbituric acid , microsome , in vitro , stereochemistry , biochemistry , food science
5‐Substituted pyrrolo[1,2‐ b ]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2‐ b ]pyridazine 5‐position. Several compound exhibit profound inhibition of lipid peroxidation in vitro . Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO 4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.