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Comparison of the Inhibition of the Cytosolic Phospholipase A 2 ‐Mediated Arachidonic Acid Release by Several Indole‐2‐carboxylic Acids and 3‐(Pyrrol‐2‐yl)propionic Acids in Bovine and in Human Platelets
Author(s) -
Lehr Matthias,
Schulze Elfringhoff Alwine
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(20009)333:9<312::aid-ardp312>3.0.co;2-y
Subject(s) - arachidonic acid , phospholipase a2 , chemistry , cytosol , platelet , indole test , ionophore , carboxylic acid , biochemistry , calcium , phospholipase a , enzyme , organic chemistry , membrane , biology , immunology
The inhibition of the cytosolic phospholipase A 2 (cPLA 2 )‐mediated arachidonic acid release by several indole‐2‐carboxylic acids and 3‐(pyrrol‐2‐yl)propionic acids was measured in intact human platelets using calcium ionophore A23187 as stimulant. The comparison of the obtained data with the inhibition data evaluated with bovine platelets showed that analogous results were obtained with both cell types.