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New Tetrahydro‐2 H ‐1,3,5‐thiadiazine‐2‐thione Derivatives as Potential Antimicrobial Agents
Author(s) -
ElShorbagi AbdelNasser
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(20009)333:9<281::aid-ardp281>3.0.co;2-e
Subject(s) - amine gas treating , antimicrobial , chemistry , enantiomer , stereochemistry , chloramphenicol , combinatorial chemistry , antibiotics , organic chemistry , biochemistry
The deacylated chloramphenicol amine D‐(—)‐threo‐2‐amino‐1‐(4‐nitrophenyl)‐1,3‐diol (D‐amine, 1a ), and its enantiomer, the L‐(+)‐threo‐form (L‐amine, 1b ), were introduced into a tetrahydro‐2 H ‐1,3,5‐thiadiazine‐2‐thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I‐III ) at N3 (type I ), N5 (type II ) or both N3 and N5 (type III ) of the THTT system. These selections were made in order to investigate the effect of combining the structural features of the THTT and the D‐amine on the antimicrobial activity, if any.