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Synthesis of Substituted Tri‐ and Tetracyclic Compounds Bearing a Pyridazine Core and their Biological Evaluation as Antimycobacterial Agents
Author(s) -
Heinisch Gottfried,
Matuszczak Barbara,
Planitzer Karin
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(20007)333:7<231::aid-ardp231>3.0.co;2-1
Subject(s) - antimycobacterial , pyridazine , chemistry , halogenation , biological activity , combinatorial chemistry , alkylation , stereochemistry , organic chemistry , biochemistry , mycobacterium tuberculosis , in vitro , catalysis , tuberculosis , medicine , pathology
Starting from substituted 3,6‐dichloropyridazine‐4‐carboxamides ( 2, 3 ) tri‐ and tetracyclic compounds ( 4, 5 ) could be smoothly prepared. Structural modifications of interest with regard to biological activity were performed by N ‐alkylation and reductive dehalogenation. The new substituted heterocyclic compounds were screened as antimycobacterial agents; the influence of the substitution pattern on activity is discussed.