Premium
Crosslinked Polyvinylalcohol Hydrogels as Vehicles for Hydrophilic Drugs
Author(s) -
Orienti Isabella,
Di Pietra Anna,
Luppi Barbara,
Zecchi Vittorio
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200012)333:12<421::aid-ardp421>3.0.co;2-q
Subject(s) - permeation , transdermal , aqueous solution , self healing hydrogels , propranolol hydrochloride , solubility , chemistry , dosage form , drug carrier , drug delivery , chromatography , polymer chemistry , organic chemistry , propranolol , membrane , pharmacology , medicine , biochemistry
Polyvinylalcohol crosslinked with succinyl, adipoyl, or sebacoyl chloride at two different degrees of crosslinking was prepared and employed as a supporting material for aqueous topical gels containing propranolol hydrochloride, which was chosen as a hydrophilic model drug suitable for transdermal delivery. We analysed the effect of the nature of the crosslinker and the degree of crosslinking on drug permeation through porcine skin by means of the permeation parameters obtained from the gels and the corresponding aqueous solution. The gels showed greater drug permeation than the liquid solution due to an increase in drug solubility in the skin. Increasing degree of crosslinking and decreasing crosslinker acyl chain length in the gel enhance the drug permeability through the skin.