Premium
Studies on Synthesis, Chromatographic Resolution, and Antiinflammatory Activities of Some 2‐Thioxo‐1,2,3,4‐tetrahydropyrimidines and Their Condensed Derivatives
Author(s) -
Tozkoparan Birsen,
Yarim Mine,
Saraç Selma,
Ertan Mevlüt,
Kelicen Pelin,
Altinok Gülçin,
Demirdamar Rümeysa
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200012)333:12<415::aid-ardp415>3.0.co;2-e
Subject(s) - chemistry , cellulose , tris , resolution (logic) , chromatography , mass spectrometry , organic chemistry , nuclear magnetic resonance spectroscopy , acetonitriles , acetonitrile , biochemistry , computer science , artificial intelligence
In this study, the synthesis of some new 2‐thioxo‐1,2,3,4‐tetrahydropyrimidines and their condensed derivatives, thiazolo[3,2‐α] pyrimidines, are described. The structures of the compounds were confirmed by IR, 1 H‐NMR, 13 C‐NMR, and mass spectroscopy. The direct high‐performance liquid chromatographic separation of the compounds on derivatized cellulose chiral stationary phases such as cellulose tris(3,5‐dimethylphenylcarbamate) (OD), cellulose tris(4‐methylphenylcarbamate) (OG), and cellulose tris(4‐methylbenzoate) (OJ) was studied. All of the compounds were screened for their antiinflammatory activity and also investigated histopathologically. Compounds 3 and 1a were found to be the most promising antiinflammatory agents in this group.