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Does [meso‐1,2‐bis(2,6‐dichloro‐4‐hydroxyphenyl)ethylenediamine]‐dichloroplatinum (II) Act on the Hormone‐Sensitive, Murine Breast Cancer as a Biological Response Modifier? Part II. Studies on the Influence of [meso‐1,2‐bis(2,6‐dichloro‐4‐hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the Specific Immune Defense in MXT‐M‐3,2 Breast Cancer Bearing Mice
Author(s) -
Schlemmer Richard,
Spruß Thilo,
Bernhardt Günther,
Schönenberger Helmut
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200012)333:12<397::aid-ardp397>3.0.co;2-f
Subject(s) - ethylenediamine , immune system , chemistry , mammary gland , biological activity , ratón , cancer , breast cancer , hormone , endocrinology , medicine , cancer research , in vitro , immunology , biochemistry , inorganic chemistry
The anti‐tumor activity of [meso‐1,2‐bis(2,6‐dichloro‐4‐hydroxyphenyl) ethylenediamine]dichloroplatinum(II) on the MXT‐M‐3,2 breast cancer implanted into B6D2F 1 mice was not significantly reduced by splenectomy or co‐administration of cyclosporine A. Neither did the use of T‐lymphocyte‐deficient NMRI ( nu/nu ) mice as hosts substantially influence its anti‐tumor effect. Obviously, [meso‐1,2‐bis(2,6‐dichloro‐4‐hydroxyphenyl)ethylenediamine] dichloroplatinum(II) does not act by an enhancement of the specific immune defense.