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Synthesis and Analgesic Activity of Some Quinazoline Analogs of Anpirtoline
Author(s) -
Rádl Stanislav,
Hezky Petr,
Proška Jan,
Krejcí Ivan
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/1521-4184(200011)333:11<381::aid-ardp381>3.0.co;2-a
Subject(s) - analgesic , quinazoline , chemistry , tramadol , quinoline , pyridine , acetic acid , pharmacology , stereochemistry , combinatorial chemistry , medicinal chemistry , biochemistry , organic chemistry , medicine
New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, quinazoline, 7‐chloroquinoline, and 7‐chloroquinazoline nuclei, have been synthesized. Their receptor binding profiles (5‐HT 1A , 5‐HT 1B ) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 4e — 4g , and 4l are at least comparable to that of clinically used drugs flupirtine and tramadol under the same conditions.