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ICAM‐1 enhances MHC‐peptide activation of CD8 + T cells without an organized immunological synapse
Author(s) -
Goldstein Julia S.,
Chen Trina,
Gubina Elena,
Pastor Richard W.,
Kozlowski Steven
Publication year - 2000
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/1521-4141(200011)30:11<3266::aid-immu3266>3.0.co;2-f
Subject(s) - immunological synapse , t cell receptor , biology , synapse , t cell , microbiology and biotechnology , cd8 , major histocompatibility complex , receptor , antigen , immunology , immune system , neuroscience , biochemistry
Abstract In addition to the TCR‐ligand interaction, other receptor‐ligand pairs, such as LFA‐1 and ICAM‐1, play a major role in the activation of T cells. Recent studies of T cell activation suggest a coordinated movement of LFA‐1 and ICAM‐1 in forming a defined zone in the immunological synapse. It is unclear from these studies whether the organized molecular geometry of the immunological synapse is necessary for ICAM‐1 enhancement of T cell activation. In this report, we demonstrate that ICAM‐1 can enhance the activation of CD8 + T cells by MHC‐peptide in the absence of an organized immunologic synapse. Therefore, although the molecular organization of the immunologic synapse may amplify stimuli, it is not an absolute requirement for either CD8 + T cell activation or the ICAM‐1 enhancement of TCR activation.