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Potentiometric Sensor for Hydroxyzine Determination
Author(s) -
Bouklouze Abdelaziz,
Elbouzekraoui Mouloudi,
Cherrah Yahia,
Hassar Mohamed,
Kauffmann JeanMichel
Publication year - 2002
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200211)14:19/20<1369::aid-elan1369>3.0.co;2-n
Subject(s) - hydroxyzine , potentiometric titration , chromatography , medicine , chemistry , pharmacology , organic chemistry , ion
A new polymeric membrane electrode has been developed for the determination of hydroxyzine. The electrode was constructed by solubilizing the hydroxyzine silicotungstate ion pair into a polyvinylchloride matrix plasticized by nitrophenyloctylether. The electrode exhibited a near‐Nernstian response (57 mV/decade) in the concentration range comprised between 1×10 −2 M and 6×10 −7 M with a lower limit of detection of 2.5×10 −7 M. The electrode response was not sensitive to pH changes between 2.8 and 6.9 and not affected by possible interfering species such as cetirizine and pharmaceutical excipients. The electrode was successfully applied to the determination of hydroxyzine in pharmaceuticals and in a dissolution profile study of tablets. The results were validated by comparison with LC and spectrophotometric assays according to the USP Pharmacopoeia methods.