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Study of Phenol‐Like Compounds Antioxidative Behavior on Low‐Density Lipoprotein Gold Modified Electrode
Author(s) -
Litescu SimonaCarmen,
Cioffi Nicola,
Sabbatini Luigia,
Radu GabrielLucian
Publication year - 2002
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200206)14:12<858::aid-elan858>3.0.co;2-u
Subject(s) - butylated hydroxyanisole , phenol , chemistry , electrode , antioxidant , low density lipoprotein , phenols , organic chemistry , cholesterol , biochemistry
A low‐density lipoprotein (LDL) modified gold electrode was designed as an evaluation model of antioxidative properties of two phenol‐like compounds: α‐tocopherol (α‐toc) and t‐butyl‐hydroxyanisole (BHA). Two sources of free radicals [2,2′‐azobis(2‐amidinopropane) dihydrochloride and H 2 O 2 ] were used to induce the lipoprotein oxidation and the “antioxidant potentiality” of the phenol‐like compounds on LDL oxidative process is reported. Two series of experiments were performed by using antioxidants either in solution or co‐immobilized on the gold electrode within the LDL layer. When dissolved in solution, α‐toc ensures a better LDL preservation than BHA; when co‐immobilized, α‐toc shows a prooxidant behavior, while BHA exhibits an efficient antioxidant action.