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Electrocatalytic Oxidation and Flow Injection Amperometric Determination of 5‐Hydroxytryptophan
Author(s) -
Cohen Jamie L.,
Widera Justyna,
Cox James A.
Publication year - 2002
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200202)14:3<231::aid-elan231>3.0.co;2-u
Subject(s) - amperometry , passivation , glassy carbon , electrode , inorganic chemistry , materials science , ruthenium , oxide , pentaerythritol , flow injection analysis , catalysis , electrochemistry , chemistry , organic chemistry , cyclic voltammetry , detection limit , chromatography , nanotechnology , metallurgy , fire retardant , layer (electronics)
The oxidation of 5‐hydroxytryptophan (5‐HTPP) at a glassy carbon electrode was not suited for electroanalysis because of surface passivation. Both mixed‐valence ruthenium oxide with cyano crosslinks (RuOx) and a pentaerythritol‐based metallodendrimer with Ru II terpyridine units (Ru II Den) provided electrocatalytic oxidation without passivation. The former was used as an electrochemically deposited film on glassy carbon, and the latter was a component of a composite electrode with a sol‐gel binder. Flow‐injection analysis with amperometric detection at constant applied potential yielded detection limits of 0.16 μM and 50 nM 5‐HTPP with RuOx and Ru II Den catalysts, respectively.