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Capacitive Creatinine Sensor Based on a Photografted Molecularly Imprinted Polymer
Author(s) -
PanasyukDelaney Tatiana,
Mirsky Vladimir M.,
Wolfbeis Otto S.
Publication year - 2002
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200202)14:3<221::aid-elan221>3.0.co;2-y
Subject(s) - molecularly imprinted polymer , materials science , capacitive sensing , polymer , nanotechnology , chromatography , chemistry , computer science , organic chemistry , selectivity , composite material , catalysis , operating system
The first reversible chemosensor to creatinine based on artificial chemoreceptors is described. The receptor layer was prepared by molecularly imprinted photopolymerization of acrylamidomethylpropanesulfonic acid and methylenediacrylamide. The polymer layer was grafted onto the surface of gold electrodes coated with an alkanethiol monolayer. Creatinine binding was detected by a decrease in the electrode capacitance. The sensor response is reversible and highly selective: no response to addition of sodium chloride, creatine, urea or glucose were observed. The detection limit for creatinine is 10 μM which is optimal for medical applications.