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Capacitive Biosensors
Author(s) -
Berggren Christine,
Bjarnason Bjarni,
Johansson Gillis
Publication year - 2001
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200103)13:3<173::aid-elan173>3.0.co;2-b
Subject(s) - biosensor , analyte , capacitive sensing , capacitance , electrode , materials science , dielectric spectroscopy , analytical chemistry (journal) , nanotechnology , chemistry , chromatography , electrochemistry , computer science , operating system
Work on a new type of biosensor, in which changes in the dielectric properties of an electrode surface are detected, started during the late 80s. The binding of an analyte to an immobilized affinity element can be detected directly without the need for a label or an indicating reaction. The changes can be determined by measuring the electrical capacitance or impedance either by using interdigitated electrodes or more commonly by potentiostatic methods. Capacitive biosensors have been used for detection of antigens, antibodies, proteins, DNA fragments and heavy metal ions. Extremely low detection limits, down below 10 −15 M, have been reached with plugged, self‐assembled recognition layers.