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An Oxygen‐Insensitive Reagentless Glucose Biosensor Based on Osmium‐Complex Modified Polypyrrole
Author(s) -
Habermüller Katja,
Ramanavicius Arunas,
Laurinavicius Valdas,
Schuhmann Wolfgang
Publication year - 2000
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200011)12:17<1383::aid-elan1383>3.0.co;2-0
Subject(s) - biosensor , polypyrrole , pyrrole , redox , electron transfer , monomer , polymer , chemistry , copolymer , combinatorial chemistry , glucose oxidase , oxygen , polymerization , osmium , electrode , polymer chemistry , chemical engineering , materials science , inorganic chemistry , catalysis , photochemistry , organic chemistry , biochemistry , ruthenium , engineering
An optimized material for the development of reagentless oxygen‐independent biosensors based on conducting polymers is described. Considering the prerequisites for a fast electron transfer between a redox enzyme and the electrode surface via an electron‐hopping mechanism, an Os‐complex‐modified pyrrole derivative with a long, flexible spacer chain has been synthesized. Copolymerization of the new mediator‐modified pyrrole monomer with pyrrole was optimized aiming on a higher mediator loading in the film. The feasibility of this material for the development of reagentless oxygen‐independent biosensors is demonstrated by entrapment of a PQQ‐dependent glucose dehydrogenase isolated from Erwinia sp. 34‐1 within this electrochemically grown redox‐polymer network.