Premium
Preliminary Contribution to the Complex Reduction Processes Involving Mitomycin C
Author(s) -
Zuman Petr,
Pérez Pedro,
Marín Dolores
Publication year - 2000
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200008)12:12<952::aid-elan952>3.0.co;2-j
Subject(s) - chemistry , hydroquinone , mitomycin c , electrochemistry , quinone , hydrolysis , combinatorial chemistry , reactivity (psychology) , anode , photochemistry , inorganic chemistry , stereochemistry , organic chemistry , electrode , medicine , alternative medicine , surgery , pathology
Electrochemical studies indicated that between pH 5 and 10 the antibiotic and cancerostatic agent mitomycin C is present in two forms in equilibrium. The quinonoid form is reversibly reduced in wave i 1 , the other form irreversibly in wave i 2 at –0.3 V more negative potentials. The conversion of the nonquinonoid form into the quinone is acid catalyzed. The hydroquinone formed in i 1 is converted into two species reduced in waves i 4 and i 5 . Further contribution of electroanalytical investigations is the distinction of three hydrolytic processes with considerably different rates: A very fast one at pH 4–5, a slower one at pH 2–3.5, and a faster one at pH<2. Products of all three hydrolytic processes are reduced in the same potential range. In the same potential range is also reduced the product, formed by a fast reaction from the two‐electron reduction product of mitomycin C. The electrochemical reactivity thus parallels the physiological one, as only products of reduction or hydrolysis of mitomycin C react with the guanine grouping of DNA.