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Voltammetry of Protonated Anesthetics at a Liquid Membrane: Evaluation of the Drug Propagation
Author(s) -
Samec Zdeněk,
Trojánek Antonín,
Langmaier Jan,
Samcová Eva,
Málek Jiří
Publication year - 2000
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200008)12:12<901::aid-elan901>3.0.co;2-6
Subject(s) - dibucaine , tetracaine , chemistry , protonation , procaine , membrane , voltammetry , lidocaine , ionic bonding , ion , analytical chemistry (journal) , biophysics , chromatography , electrode , electrochemistry , pharmacology , anesthesia , organic chemistry , biochemistry , medicine , biology
Voltammetric measurements are used to study the transfer of protonated forms of local anesthetics (procaine, tetracaine, prilocaine, bupivacaine, lidocaine, dibucaine) across a supported o ‐nitrophenyl octyl ether ( o ‐NPOE) membrane. Ion diffusion coefficients and ion transfer potentials were obtained, which are comparable with those inferred from measurements at a water–o‐NPOE interface. It is shown that the pharmacological potency of local anesthetics correlates with standard ion transfer potentials of their protonated forms. It is proposed that the drug propagation involves the transfer of the ionic rather than uncharged anesthetic across the cell membrane.