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Electroanalysis of Glucose in Transcutaneously Extracted Samples
Author(s) -
Tierney M. J.,
Kim H. L.,
Burns M. D.,
Tamada, J. A.,
Potts R. O.
Publication year - 2000
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/1521-4109(200005)12:9<666::aid-elan666>3.0.co;2-c
Subject(s) - iontophoresis , amperometry , biosensor , biomedical engineering , pipette , chromatography , chemistry , glucose oxidase , medicine , electrode , biochemistry , electrochemistry , radiology
Glucose can be extracted through intact skin by electroosmosis upon application of a low‐level electrical current. The amount of glucose extracted has been shown previously to correlate with blood glucose level. An amperometric, GOx‐based biosensor was used to measure the amount of glucose in samples extracted from a nondiabetic volunteer every twenty minutes for five hours. The blank‐subtracted current output from this sensor accurately tracked blood glucose changes and correlated with the capillary blood glucose values (average r >0.93) and a time lag of twenty minutes. This proof‐of‐feasibility is a prerequisite to the development of an integrated, wearable glucose monitor for diabetics combining both biosensor and iontophoresis functions.