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Gel Machines Constructed from Chemically Cross‐linked Actins and Myosins
Author(s) -
Kakugo A.,
Sugimoto S.,
Gong J.P.,
Osada Y.
Publication year - 2002
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(20020816)14:16<1124::aid-adma1124>3.0.co;2-m
Subject(s) - myosin , actin , polymer , materials science , biophysics , protein filament , biochemistry , biology , composite material
An ATP‐fueled soft gel machine reconstructed from polymer‐crosslinked actin muscle protein (“giant‐actin”) and analogously modified myosin has been built by Osada and co‐workers. The “giant‐actin” gel filaments (several 1000 times larger by volume than native actin, see Figure) move along their myosin counterparts as fast as native F‐actin. Such machines should work inside their body of origin without eliciting immunoreactions.