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A Chemically Synthesized Artificial Pancreas: Release of Insulin from Glucose‐Responsive Hydrogels
Author(s) -
GuiseppiElie A.,
Brahim S.I.,
Narinesingh D.
Publication year - 2002
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(20020517)14:10<743::aid-adma743>3.0.co;2-h
Subject(s) - self healing hydrogels , glucose oxidase , materials science , insulin , membrane , polymer , copolymer , artificial pancreas , chemical engineering , nanotechnology , polymer chemistry , biosensor , biochemistry , chemistry , composite material , diabetes mellitus , biology , endocrinology , type 1 diabetes , engineering
Contact‐lens‐like polymeric hydrogels that are glucose‐responsive have been synthesized by entrapping the enzyme glucose oxidase (GOx) within the polymer network. The polymeric hydrogels are pH‐sensitive and act as glucose‐responsive membranes effecting the release of insulin (see Figure). The release profile from a multi‐laminated hydrogel device displays a sustained release of insulin in response to glucose.