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Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon
Author(s) -
Chin V.,
Collins B. E.,
Sailor M. J.,
Bhatia S. N.
Publication year - 2001
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(200112)13:24<1877::aid-adma1877>3.0.co;2-4
Subject(s) - materials science , silicon , nanoporous , substrate (aquarium) , fluorescence microscope , albumin , nanotechnology , chemical engineering , urea , biophysics , porous silicon , fluorescence , organic chemistry , biochemistry , optoelectronics , chemistry , biology , ecology , physics , engineering , quantum mechanics
Porous silicon is a substrate highly compatible with living cells! Particularly after treatment of the surface with adhesive serum proteins, primary rat hepatocytes are easily attached while staying viable (shown by fluorescence microscopy with a vital dye—see Figure). Cells thus immobilized remain active even over a two week period, as their unchanged albumin and urea production reveals.