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Novel Colloidal Materials for High‐Throughput Screening Applications in Drug Discovery and Genomics
Author(s) -
Trau M.,
Battersby B. J.
Publication year - 2001
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(200107)13:12/13<975::aid-adma975>3.0.co;2-#
Subject(s) - bead , nanotechnology , materials science , drug discovery , throughput , high throughput screening , combinatorial chemistry , fluorescence , colloid , computer science , biology , chemistry , organic chemistry , bioinformatics , telecommunications , physics , quantum mechanics , composite material , wireless
Tracking the reaction history is the means of choice to identify bioactive compounds in large combinatorial libraries. The authors show two approaches for synthesis on silica beads: (a) addition of a “reporter dye tag” during each synthesis step, which attaches itself to the bead by colloidal forces and (b) encapsulating arrays of fluorescent dyes into the beads to encode them uniquely, for recognition with a flow cytometer after each reaction step.