Premium
Protein Adhesion at Poly(ethylene glycol) Modified Surfaces
Author(s) -
Snellings G. M. B. F.,
Vansteenkiste S. O.,
Corneillie S. I.,
Davies M. C.,
Schacht E. H.
Publication year - 2000
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(200012)12:24<1959::aid-adma1959>3.0.co;2-v
Subject(s) - ethylene glycol , protein adsorption , materials science , biocompatibility , adhesion , peg ratio , surface plasmon resonance , polymer , adsorption , surface modification , nanotechnology , chemical engineering , biophysics , nanoparticle , organic chemistry , chemistry , composite material , finance , economics , engineering , metallurgy , biology
The inhibition of protein adsorption to the surfaces of biomedical devices is a crucial requirement for avoiding implant‐associated infections or thrombus formation on blood‐contacting artificial surfaces and thus for increasing the long‐term biocompatibility of the devices. Here, the use of surface plasmon resonance and scanning force microscopy using protein‐modified tips (see figure) to study protein adhesion on poly(ethylene glycol) (PEG) grafted polymer materials is discussed. The PEG‐rafted materials are revealed to have significantly reduced affinity to proteins.