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Dendrimers with Attached Helical Peptides
Author(s) -
Higashi N.,
Koga T.,
Niwa M.
Publication year - 2000
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/1521-4095(200009)12:18<1373::aid-adma1373>3.0.co;2-k
Subject(s) - dendrimer , materials science , peptide , polymerization , nanotechnology , biophysics , polymer chemistry , polymer , chemistry , biochemistry , composite material , biology
The attachment of peptides to the surface of spherical dendrimers via graft polymerization is described here (see Figure). It is shown that the resulting peptide dendrimers display greatly enhanced helicity compared to non‐dendrimer‐based analogues. This effect is attributed to aggregation of peptide segments on the dendrimer surface.