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Investigation of flow and material induced hemolysis with a Couette type high shear system
Author(s) -
Klaus S.,
Paul R.,
Reul H.,
Mottaghy K.,
Glasmacher B.
Publication year - 2001
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/1521-4052(200112)32:12<922::aid-mawe922>3.0.co;2-h
Subject(s) - hemolysis , couette flow , shear (geology) , chemistry , materials science , composite material , physics , flow (mathematics) , immunology , medicine , mechanics
Damage of red blood cells (hemolysis) in miniaturized pump systems for heart support is induced by contact with artificial surfaces and high mechanical shear forces. In vitro experiments with porcine blood under well defined material and flow conditions with a new Couette model showed hemolysis not starting until shear stresses of 400 Pa and exposure times of 400 ms. Hemolysis in general was much lower than predicted in earlier investigations. Heparinized blood revealed a more sensitive behaviour as compared to citrated blood (CPDA‐1).