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A Measurement Model of Disease Damage in Paired Organs
Author(s) -
Martus Peter
Publication year - 2001
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/1521-4036(200112)43:8<927::aid-bimj927>3.0.co;2-k
Subject(s) - gynecology , medicine
Diagnostic test can be used to classify subjects as “diseased” or “undiseased”. If measurements are obtained on a quantitative scale they may serve additionally to quantify the damage caused by the disease. If a whole bundle of measurements is available but no gold standard exists, the evaluation of these measurements may be improved by using latent variables. The subject of this investigation is an application of latent variable techniques in the evaluation of diagnostic measurements concerning paired organs. A method is presented which allows to quantify the association between the true disease damage of affected organs. Furthermore, the corresponding association of the error components of several measurements can be quantified. The method is based upon a one factor model of the diagnostic measurements. The method supports the investigation of the pathogenetic process of the underlying disease and the improvement of diagnostic measurements. It is applied to data from the Erlangen Glaucoma Registry.