Premium
Matched Case Control Studies with Random Exposure Effects
Author(s) -
Chowdhury Sadeq R.,
McGilchrist C.A.
Publication year - 2001
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/1521-4036(200106)43:3<271::aid-bimj271>3.0.co;2-9
Subject(s) - overdispersion , statistics , mathematics , random effects model , econometrics , quasi likelihood , computer science , count data , medicine , poisson distribution , meta analysis
A method for analysing matched case control data in presence of overdispersion or correlation between observations within matched sets is presented. A generalised linear mixed model approach is adapted to account for overdispersion by allowing random exposure effects. Expressions for the elements of the estimation equation are derived and a strategy for achieving efficiency in computing is discussed. Results from simulation studies and two applications are presented.