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Uniformly sized molecularly imprinted polymers (MIPs) for 17β‐estradiol
Author(s) -
Piscopo Laura,
Prandi Cristina,
Coppa Marco,
Sparnacci Katia,
Laus Michele,
Laganà Aldo,
Curini Roberta,
D'Ascenzo Giuseppe
Publication year - 2002
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/1521-3935(200207)203:10/11<1532::aid-macp1532>3.0.co;2-c
Subject(s) - ethylene glycol dimethacrylate , polystyrene , polymer chemistry , molecularly imprinted polymer , copolymer , polymer , polymerization , amphiphile , materials science , ethylene glycol , monomer , toluene , chemical engineering , chemistry , organic chemistry , methacrylic acid , selectivity , catalysis , engineering
Molecularly imprinted polymers (MIPs) for 17β‐estradiol were prepared following a multistep procedure including swelling and polymerization using polystyrene seeds, 4‐vinylpyridine as the functional monomer and ethylene glycol dimethacrylate (EDMA) as crosslinker. Dibutylphthalate (DBF) and toluene were employed as swelling and porogenic compounds. All the samples showed a monomodal and very narrow diameter distribution with mean diameter values in the 2.0–4.7 μm range. The microspheres prepared in the presence of the template molecule present surface available vinyl pyridine unit content higher than those prepared without the template. The amphiphilic nature of the pre‐polymerization complex between vinyl pyridine and 17β‐estradiol can be claimed to be responsible for a preferential location of the vinyl pyridine units at the microsphere surface. The ability of molecular recognition depends on the accessibility of interaction sites located on surface of polymeric particles that increases when the ratios EDMA/polystyrene seed and DBF/polystyrene seed increase.TEM micrograph of sample PI4 .