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Fluorescent Cyclodextrin/Peptide Hybrids with a Novel Guest‐Responsive Chemosensor in the Peptide Side Chain
Author(s) -
Toyoda Takayuki,
Mihara Hisakazu,
Ueno Akihiko
Publication year - 2002
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20021001)23:15<905::aid-marc905>3.0.co;2-o
Subject(s) - fluorescence , side chain , cyclodextrin , peptide , intramolecular force , chemistry , combinatorial chemistry , molecule , stereochemistry , organic chemistry , biochemistry , polymer , physics , quantum mechanics
Peptides bearing β ‐cyclodextrin and 4‐( N,N ‐dimethylamino)benzoyl (DMAB) units in the peptide side chains were prepared as chemosensors for molecule detection. The DMAB unit was expected to be included into the cyclodextrin cavity intramolecularly. However, these peptides exhibited no twisted intramolecular charge transfer fluorescence and the normal fluorescence intensity decreased upon the addition of 1‐adamantanol as an exogenous guest, indicating that the DMAB units are shallowly included in the cyclodextrin cavities.