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Enzymatic Degradation of Semi‐IPN Hydrogels Based on N‐ Isopropylacrylamide and Dextran at a Specific Temperature Range
Author(s) -
Kumashiro Yoshikazu,
Lee Won Kyu,
Ooya Tooru,
Yui Nobuhiko
Publication year - 2002
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/1521-3927(20020401)23:7<407::aid-marc407>3.0.co;2-7
Subject(s) - self healing hydrogels , dextran , cloud point , degradation (telecommunications) , poly(n isopropylacrylamide) , lower critical solution temperature , chemical engineering , materials science , swelling , chemistry , biophysics , polymer chemistry , polymer , copolymer , aqueous solution , biochemistry , composite material , organic chemistry , computer science , telecommunications , engineering , biology
The temperature‐dependent enzymatic degradation of semi‐IPN hydrogels consisting of dextran grafted with thermo‐responsive chains (lower cloud point) and a thermo‐responsive crosslinked matrix (higher cloud point) was examined. Enzymatic degradation of the semi‐IPN hydrogel was significantly inhibited below the lower and above the higher cloud point. Only between both cloud points, enzymatic degradation proceeded. The designed semi‐IPN hydrogel is therefore advantageous to achieve enzymatic degradation at a specific temperature range.